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Areas Requiring Further Investigation Further research is needed to clarify long-range receptor signaling behavior, tissue-specific pathway effects, molecular signaling durability, model-to-human translation, and how findings vary across study designs

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Conti, S

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The profound anatomical and pathophysiological disparities between these models and human disease create a significant translational gap. Acknowledging these limitations is key to interpreting preclinical data cautiously and designing more relevant experimental paradigms