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Two weeks later, the rats were anesthetized with 10% chloral hydrate

This has been proposed to be due to induction of apoptosis (programmed cell death) in sebaceous glands, meibomian glands, neuroblastoma cells, hypothalamic cells, hippocampus cells, Dalton's lymphoma ascites cells, B16F-10 melanoma cells, neuronal crest cells, stem cells and others, [36] that it changes epigenetics [37] and shortens telomeres

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses

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