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25 A subsequent single-center placebo-controlled, multiple-ascending dose, phase 1b trial examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of cagrilintide in combination with semaglutide

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These results suggest that GHR expression in AgRP neurons is unnecessary for the regulation of energy homeostasis under normal circumstances or for the response to key hormones that rely on AgRP neurons to modulate energy homeostasis

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