Published patent applications are not granted patents
[17] [18] Once reconstituted, the peptide is no longer protected by the stable, dehydrated matrix of the lyophilised form
Some people are naturally more responsive to GLP-1 agonism
The same bacterial fermentation producing hydrogen sulfide (sulfur burps) also produces other gases and short-chain fatty acids that can accelerate colonic transit and cause watery stools
Intramuscular injection can cause increased pain, faster drug absorption than intended, and a higher risk of bruising
At the same time, gross spending increased ninefold, from about $1 billion in 2019 to almost $9 billion in 2024, and gross spending per GLP-1 prescription reached $1,000 in 2024