Research from the SURMOUNT-4 trial showed that participants who discontinued tirzepatide regained roughly two-thirds of the weight theyd lost within one year
A spinal tap (lumbar puncture) to test your cerebrospinal fluid (CSF) can also detect signs of infection or other changes in your cerebrospinal fluid
Borowczyk, K., Krawczyk, M., Kubalczyk, P
The medication is still binding to receptors, still activating pathways, but the intensity has dulled
Creating a sustainable food future: A menu of solutions to feed nearly 10 billion people by 2050
The Clinical Trial Evidence Behind Tirzepatide's Market Entry The SURMOUNT-1, SURMOUNT-2, and SURMOUNT-3 trials established tirzepatide's efficacy for weight loss before FDA approval, with patients losing 20-22% of baseline body weight over 68 weeks at the highest doses