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Of interest, the down-expression of ACC2 results from an epigenetic process linked to histone deacetylation at the ACACB promoter by Sirtuin 1/6 that are activated by high cytosolic NAD + levels associated with enhanced FAO and reduced glucose metabolism

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doi: 10.1186/s12888-023-05324-4 60 GaoHLiXChenXHaiDWeiCZhangLet al

Who May Be at Higher Risk for Weight Regain and How to Prepare Patients with type 2 diabetes, polycystic ovary syndrome (PCOS), metabolic syndrome, or strong family history of obesity face higher weight regain risk due to underlying insulin resistance and dysregulated appetite signaling

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