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Topiramate is usually initiated at a dose of 25 mg daily, taken in the morning, and increased by 25 mg each week as needed

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Another placebo-controlled study 35 reported clinical improvement alongside circadian biomarker assessment, noting that seven participants had more than a 10-point decrease in DSM-III-R depression score after ALC treatment

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Functional training involves performing exercises that replicate the movements commonly encountered in sports, such as cutting, pivoting, and jumping