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In receptor-binding and cellular-signaling research, MT-2 acts as a non-selective agonist across the melanocortin receptors: MC1R (associated with melanocyte pigmentation), MC3R and MC4R (central receptors implicated in energy-homeostasis and appetite research), and MC5R

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Subsequent studies have confirmed these observations, with research showing GHK-Cu can increase hair follicle size and improve hair shaft thickness in experimental models