fda drug safety communication semaglutide naion 2025 Reposting as I get asked a lot this. Bottom line: Causation vs Association: Most of the evidence is observational. That means the studies show associations (people using these drugs had somewhat higher Ophthalmic complications with semaglutide and

Excessive protein intake (over 50 grams at one meal) may worsen nausea or stomach discomfort in your first few weeks on semaglutide

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It may compromise weight control where patients are taking GLP-1RAs and GLP-1/GIPRAs for this indication

Well a simple answer is it depends

Put plainly, when theres less body weight to maintain, the body does less work but it also becomes extra efficient, burning fewer calories than predicted and nudging weight back up

Nausea is one of the most frequently reported side effects associated with retatrutide in clinical trials to date, as documented in the Phase 2 randomised controlled trial published in the New England Journal of Medicine in June 2023 (Jastreboff et al., NEJM 2023)