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A Phase 2 trial evaluating doses as low as 1 mg demonstrated measurable improvements in HbA1c levels and body weight, with fewer gastrointestinal side effects compared to higher doses, suggesting that starting with microdoses may enhance tolerability

Sci Transl Med 2013;5:209ra151.ArticlePubMed 52

Any 'dosing schedule' circulating online is not backed by an approved label

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doi: 10.1111/micc.12186 210 Carranza-NavalMJDel MarcoAHierro-BujalanceCAlves-MartinezPInfante-GarciaCVargas-SoriaMet al

Additionally, patients should have regular thyroid function monitoring, as weight loss itself can sometimes necessitate adjustments to levothyroxine dosing