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Overall survival analysis of EXAM, a phase III trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma
It has been reported that this is one of the most common pharmaceutical products to cause DILI.15 Mortality rates have been approximated at 0.4% in overdose patients, translating to 300 deaths annually in the United States.1 Although toxic ingestions causing hepatic failure are usually in excess of 150 mg/kg, an increasing number of reports has arisen to suggest that lower doses of APAP may confer acute liver injury and liver failure.14 A so-called therapeutic misadventure phenomenon, as coined by Zimmerman et al ., is becoming increasingly acknowledged, as some patients have presented with acute liver failure despite consumption of safe doses of APAP
Neuropharmacology 80 , 103114 (2014)
HP (119), SSO (120), and ECD (121) mainly enhance antioxidant capacity by regulating the AMPK/p53/Nrf2 signaling pathway
