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Paracetamol and NSAIDs have the benefit of bearing a low risk of addiction, dependence, tolerance, and withdrawal, but, unlike opioid medications, may damage the liver

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This is short-term stress, the fight-or-flight response, mediated by the hormones epinephrine and norepinephrine from the adrenal medulla via the SAM pathway

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When combined with insulin or sulfonylureas, dose adjustments of these medications are frequently necessary to reduce the risk of hypoglycemia, as the glucose-lowering effects may be additive

This decision should be individualized based on your specific clinical context and treatment goals