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Knott SRV, Wagenblast E, Khan S, et al

[2] [5] Hydropersulfides are prototypical reactive sulfur species

Supplementary Video 1 (download MP4 Sunflower seed assay in a control mouse (C57BL/6N male)

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Importantly, these differences shape downstream receptor activation: peripherally derived hydrophobic or unconjugated bile acids more effectively engage membrane receptors such as TGR5 and S1PR2, producing rapid non-genomic signaling effects, whereas locally synthesized oxysterol-derived ligands preferentially modulate nuclear receptors including FXR and PXR, influencing transcriptional and metabolic programs within neurons and glia (82)