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It is composed of three amino acids: glycine, glutamine and cysteine

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Collectively, these studies suggest somewhat paradoxically that to maximize the induction of ferroptosis by GSH depletion it may be necessary to ensure that cancer cells are otherwise as metabolically active as possible

Cancer Res 75(21):45044516 Lugano R et al (2018) CD93 promotes beta1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

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5-FU selectively kills cancer cells by increasing reactive oxygen species (ROS) to cytotoxic levels