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Figure 2 Recently, the whole dogma of the role of intestinal GLP-1, envisioning the traveling from the gut to the liver and ultimately reaching the pancreatic -cells to bind its GLP-1R has been questioned in transgenic mice (204)

Originally, its use was limited to treating children with a complete deficiency of this hormone, and until the mid-1980s, it was obtained from the pituitary glands of cadavers ( Although these preparations were biologically active, their production was limited due to the scarcity of this natural source

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Medications like Ozempic, Mounjaro, Zepbound, and Wegovy have become household names, offering effective pathways to improved health outcomes

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