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Years of dedicated research and clinical practice led Gordon to develop a deep understanding of the intricate relationship between the endocrine system and the brain

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It was first used to describe a cell death process induced by a small molecule called erastin, which inhibits the intake of cystine, resulting in glutathione depletion and inactivation of the phospholipid potentially toxic lipid peroxidase 4 (GPX4) (Yang et al., 2014)