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GLP-1 receptor agonists have been shown to reduce systemic inflammation through several mechanisms: Reducing oxidative stress: GLP-1s can reduce oxidative stress, a key contributor to inflammation

This narrative review synthesizes current preclinical and human evidence on the bidirectional interactions between GLP-1 RAs and the intestinal microbial ecosystem, with particular attention to microbial composition, metabolite production (including short-chain fatty acids and bile acids), intestinal barrier integrity, and inflammatory signaling

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& Donnelly, J