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Swerdlow RH, Khan SM

Before starting Wegovy , clinicians should: Conduct a comprehensive medical history focusing on pancreatic conditions, gallbladder disease, and alcohol use Assess baseline metabolic parameters including lipid profile (triglycerides) Review current medications that might increase pancreatitis risk Provide detailed patient education about warning symptoms Document informed consent discussion including pancreatic and gallbladder risks During treatment , ongoing monitoring includes: Regular clinical assessments at each dose escalation and then periodically to evaluate tolerance, efficacy, and adverse effects Symptom surveillance : Patients should be asked specifically about abdominal pain, nausea, or digestive changes at each visit Laboratory monitoring : While routine pancreatic enzyme testing is not recommended for asymptomatic patients, lipid profiles should be monitored, particularly in those with baseline hypertriglyceridaemia [5] [8] Weight loss monitoring : Patients should be informed that rapid weight loss increases gallstone risk and should report symptoms such as right upper quadrant pain [21] [22] Patient safety advice includes: Stop Wegovy immediately and seek medical attention for persistent or severe abdominal pain Call 999 or go to A&E for severe symptoms

While the new data were largely positive, Lilly acknowledged that one cardiovascular outcomes study showed a numerically higher rate of major adverse cardiovascular events among patients receiving retatrutide compared with placebo

Research shows that SSRIs reduce cardiovascular events (heart attacks, strokes, deaths) in people with both depression and cardiovascular risk, especially those whove already had a cardiac event

For the most up-to-date recommendations specific to dental care, dentists should refer to the Therapeutic Guidelines: Oral and Dental Version 4 , published in late 2025 [1] [3]

Warnings: Do not exceed recommended dose