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The confusion between metabolic rate and appetite hormones drives this myth

For some overloading their system with a mega-dose shot of synthetic B12 can actually make them pretty sick because because they cant clear or convert that form of B12 very well

Majerus et al., 1971

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Association between long-term quinine exposure and all-cause mortality

Therefore, the upcoming phase III and post-marketing studies should stratify efficacy and safety endpoints by sex and menopausal status