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The cellular reduction of LA to DHLA is accomplished by NAD(P)H-driven enzymes, thioredoxin reductase, lipoamide dehydrogenase, and glutathione reductase
The resulting histamine overload causes systemic inflammation, leading to classic MCAS symptoms like sudden hives, flushing, severe gastrointestinal distress, rapid heart rate (tachycardia), and sudden intolerances to previously safe foods
As a tri-peptide composed of three amino acidscysteine, glycine, and glutamateglutathione plays a pivotal role in detoxification, antioxidant defense, and immune function
Participants consumed the capsules two hours after a standard meal, followed by whiskey (0.78 g/kg body weight) and snacks
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