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Second, tirzepatides approval is specific: it is authorized for type 2 diabetes and for chronic weight management under defined conditions, not as a general-purpose research chemical

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148,149 The Met-358 is at the P1 position, which is located in the reactive site, and determines anti-protease activity of AAT

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PMID: 27602354 4 Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

FIGURE 9 Statements Data availability statement The original contributions presented in this study are included in this article/Supplementary material, further inquiries can be directed to the corresponding author