I imagine the answer is yes, especially if they have high blood pressure or elevated lipids but again with close monitoring as the weight loss is clearly extremely potent
NICE recommends that patients receive support from a multidisciplinary team delivering comprehensive weight management programs, emphasizing calorie restriction, increased physical activity, and behavioural interventions for long-term success by trained professionals [7]
Use that tolerance for occasional flexibility, not habitual early dosing
Do not try to walk it off. Lowering your center of gravity prevents injury from a fall
5.4.2 Effects on liver Despite the lack of expression of GIPR (41, 191) and GLP-1R (192, 193) in hepatocytes, both GIP and GLP-1 have indirect effects on hepatic lipid and glucose metabolism (194)
In type 2 diabetics, the HbA1c decrease, a blood sugar marker, spanned 1.3 to 2.0% in the studies, depending on dose