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10,13 In contrast to SGLT-2 inhibitors, GLP-1RAs do not significantly prevent decreases in estimated glomerular filtration rate or increases in creatinine levels
Studies have shown that IF significantly enhances GH secretion and elevates insulin-like growth factor binding protein 1 (IGFBP1) levels up to fivefold [42], thereby modulating IGF-1 bioavailability and enhancing autophagy, lipolysis, and muscle preservation [42, 43]
Acute kidney injury: Sudden kidney failure, particularly in patients who become dehydrated from gastrointestinal side effects
This result was consistent with the alleviated synovial inflammation and attenuated cartilage erosion in the SP@M group (Fig