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A paper published this week in JAMA Psychiatry found semaglutide, the active ingredient in GLP-1 drugs like Ozempic and Wegovy, "significantly improved" motivation in patients with major depressive disorder, or MDD a promising finding because lack of motivation and related disruptions to the brains reward pathways play a critical role in many other psychiatric conditions as well

doi: 10.1016/J.OPHTHA.2024.08.023 81 CheungNMitchellPWongTY

You and your doctor make that call together, visit by visit

The highest doses studied 8 mg and 12 mg were associated with the greatest weight loss outcomes in trial data, but also with a higher incidence of side effects

You are never pushed to increase faster than youre ready, and your long-term dose is chosen based on what works best for your body, not a preset target

A concentration like 5 mg/mL (by adding 3 mL of Bac Water) or 3 mg/mL (by adding 5 mL) are common and easy to work with