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That is a consistent pattern of failure to demonstrate the primary endpoint: significant fat reduction in humans

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Participants were randomized to receive once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) or placebo for 72 weeks, including a 20-week dose-escalation period

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Moreover, although supplementation with inulin-type fructans inhibited expression of certain pro-inflammatory genes in the colon (e.g., inducible nitric oxide synthase, TNF-), it also reduced sIgA secretion in the colon