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Structural behavior of the endothelial Glycocalyx is associated with pathophysiologic status in septic mice: an integrated approach to analyzing the behavior and function of the Glycocalyx using both Electron and fluorescence Intravital microscopy
doi: 10.1038/nature07416 137 PaludanCSchmidDLandthalerMVockerodtMKubeDTuschlTet al
Figure 4 illustrates the antimicrobial mechanisms of polyphenols, illustrating the disruption of microbial cell structures (lipopolysaccharide cell wall, peptidoglycan cell wall, phospholipid bilayers, cell membrane proteins) and the impairment of essential cellular functions (inhibition of DNA gyrase and RNA synthesis, pore formation causing leakage, damage to membrane lipid bilayers, inhibition of enzyme activity, disruption of cell wall biosynthesis, and inactivation of lipopolysaccharide) in bacteria such as S
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