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Furthermore, preclinical pharmacokinetic studies showed better C max , T max and AUC [13]

Some patients may remain on a maintenance dose, while others may stop treatment gradually under medical supervision

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The European Medicines Agency (EMA) and Heads of Medicines Agencies (HMA) have published recommendations in tackling the shortages, warning patients that the medications should only be obtained with a prescription and through a pharmacist, cautioning against online purchases except from trusted sources, where there is proper medical supervision (EMA 2024

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