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Keywords: glucagon-like peptide-1 receptor agonists, neuroprotection, axonal injury, diabetic neuropathy (DN), multiple sclerosis (MS), Schwann cells, olfactory ensheathing cells, oligodendrocytes 1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from gut enteroendocrine cells in response to food intake, and display insulinotropic actions by stimulating specific G-protein linked GLP-1 receptor (GLP-1R) on the pancreatic cells