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Electron microscopic analysis of FTD and amyotrophic lateral sclerosis patients with TDP43 pathology revealed prominent mitochondrial impairment, including abnormal and/or depleted cristae, concordant with ultrastructural changes observed in both cellular and animal models of TDP43 proteinopathy (Wang et al., 2019)

The Intensifying GLP-1 Race While Novo Nordisk recently secured FDA approval for an oral version of semaglutide becoming the first to market an oral GLP-1RA for obesity Eli Lilly continues to lead in injectable sales with: Zepbound (obesity) Mounjaro (type 2 diabetes) Lilly is also awaiting an FDA decision on its oral candidate, orforglipron

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