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The available evidence supports the importance of GLP-1 and GIP as key DPP-4 substrates required for potentiating glucose-stimulated insulin secretion and reduction of glycemia following enteral glucose challenge (1113)

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Animal studies show potential fetal risks, though human pregnancy data remain limited

Banks WA, Burney BO, Robinson SM

New York: Marcel Dekker

These findings are aligned with prior research, including the randomized study by Kahal et al