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It has long been known that TRT suppresses natural testosterone production through a negative feedback loop that suppresses natural gonadotrophin production

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Overall, while these independent studies suggest that gut-derived GLP-1 minimally contributes to beta-cell GLP-1R stimulation, a fundamental limitation to these interpretations is that these studies do not specifically manipulate alpha-cell GLP-1, as these models are deficient in all proglucagon-derived peptides

These findings remain investigational pending the completion of phase 3 trials and regulatory review

Hiromura, M

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