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Other investigations indicate that chronic treatment with riluzole, which includes a reduction in glutamatergic neurotransmission among its mechanisms of action, attenuates the spread of tauopathy in rodent models (280)

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It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)

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Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T