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If too much fluid is made or not enough is re-absorbed, the CSF can build up

They do this by decreasing the activity of the protein breakdown pathway, and also by decreasing the expression of several complexes involved in protein breakdown

Zhang L, Wu P, Zhang L, SreeHarsha N, Mishra A, Su X

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16 : 14 Thal LJ, Carta A, Clarke WR, Ferris SH, Friedland RP, Petersen RC et al