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Mounjaro, prescribed for type 2 diabetes, has broader insurance coverage because it is classified as a diabetes medication

However, the medications also have significant side effects, including unintended muscle mass loss, nutritional deficiencies, a potential for increased risk of miscarriage or birth defects, and severe mental health issues like depression and suicidal thoughts

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aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)

The triple hormone receptor agonist retatrutide has shown weight loss reductions of over 30% in some phase 3 trial participants a level long associated with bariatric surgery according to its manufacturer Eli Lilly