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Female mice, aged 6 to 8 weeks, from these backgrounds were used in all experiments

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

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In the same way, CAR-T cells therapy targeting uPAR protein displays a huge in vitro and in vivo senolityc activity and could be considered in a close future as an alternative solution to definitively eradicate senescent cells in rejuvenation or to treat age-related diseases

However, the high incidence and recurrence rate of kidney stones remain unsolved, which motivates us to continue researching the mechanism behind kidney stone formation [4]