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Lipoic acid has been shown to inhibit the JNK pathway and IRS1 serine phosphorylation, resulting in improved insulin sensitivity

Tong Z, Chatterjee D, Deng D, Veeranki O, Mejia A, Ajani JA, Hofstetter W, Lin S, Guha S, Kopetz S , Krishnan S, Maru D

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Peptides work through specific receptor mechanisms while small molecules like NAD+ precursors, resveratrol, or nootropics target different cellular pathways