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Crucially, going higher than 1mg/day didn't improve results suggesting there's a saturation point where the receptors are fully occupied and more compound doesn't help

A microdose that seems trivially small after one injection becomes pharmacologically relevant after four to five weeks of accumulation

Reducing body weight could lower inflammation, which is key to managing HS

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Fonseca SG, Ishigaki S, Oslowski CM et al (2010) Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells