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They amplify it

Skin brightening supplements might be one of the controversial topics in the area of dermatology

But the reviewers graded the evidence as very low quality, with high risk of bias, and the trials were concentrated in a handful of countries: three in China, one in Russia, one in Romania, one unclear

Also see: Which supplements, foods or diet and lifestyle changes help relieve acid reflux (heartburn), and which worsen it

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The heterogeneity test showed statistical heterogeneity among studies (RBW: 2 = 92%, p 0.10