Alterations in the volume of distribution and clearance resulting from other mechanisms of action (eg, reduced fat mass, changes in cytochrome P450 activity, and glomerular filtration rate) are key factors in determining pharmacokinetics
69 Another meta-analysis of RCTs revealed that GLP-1 receptor agonist therapy lasting more than 52 weeks was linked to a significantly lower risk of fractures compared to placebo or alternative antidiabetic treatments
Foretz, M., Guigas, B., Bertrand, L., Pollak, M
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Young recalls that the moment he looked at Eng's results of some tests of exendin-4 in diabetic mice, he realised it could be a drug (Winkler, Cohen)