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Under oxidative stress, HO-1 expression is upregulated, enhancing cellular resilience through its protective functions 114

Under these circumstances a thiyl radical is formed that will initiate and propagate an oxygen-dependent chain reaction, involving peroxyl radical formation that will lead to further consumption of intracellular GSH (Quijano et al., 1997)

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Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease

Niacinamide: Reduces dark spots and enhances skin barrier function