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It was also demonstrated that at least a subset of alpha cells in human islets express PC1/3 and are therefore producing and releasing GLP-1 in response to physiological stimuli [63]
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GLP-1 and GIP receptors are expressed on various immune cells, including monocytes, macrophages, and lymphocytes
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however, some studies have demonstrated limited benefits of intensive glycemic control for T2D patients as only modestly prevents or delays the progression of DPN and CAN in patients with T2D, possibly because of undiagnosed hyperglycemia and multiple combined risk factors
doi: Talenezhad, N., Mohammadi, M., Ramezani-Jolfaie, N., Mozaffari-Khosravi, H
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