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Specifically, we detected higher expression of the ferritinophagy mediator NCOA4 (encoding nuclear receptor coactivator 4, which binds to ferritin and delivers it to the autophagy-lysosomal machinery) 63 , as well as MCOLN1 (encoding mucolipin transient receptor potential cation channel, also known as TRPML1), which transports iron from the lysosomes to the cytoplasm 67 and is required for lysosomal biogenesis 68 (Fig

Oxidative stress is represented in the model by the concentration of H 2 O 2

If the result shows too small a volume of liquid to measure accurately (for example, less than 1 unit), try increasing the amount of liquid added to the vial (for example, to 2 ml) and calculate again

The influence of iron on bone metabolism disorders

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History of pancreatitis and severe gastrointestinal disease (such as severe gastroparesis) are important precautions, though not absolute contraindications