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Both medications carry a risk for rare but serious side effects, including pancreatitis and possible thyroid C-cell tumors (seen mainly in animal studies)

Bitter orange extract, standardized for synephrine, is a well-known thermogenic agent that stimulates the sympathetic nervous system, promoting increased energy expenditure and fat breakdown

Thigh and upper arm subcutaneous tissue serve as alternative sites for rotation

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Monitor urine color as a hydration indicator