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The scope of the review is intentionally selective rather than exhaustive, focusing on peptidereceptor systems that demonstrate biological plausibility, mechanistic coherence, and unmet therapeutic potential, yet lack approved therapeutic analogs or advanced clinical programs
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241 In -cells of patients with T2DM, the ability of GLP-1(936) to inhibit glucagon secretion is lost
This approach aligns with clinical guidance to listen to the body and avoid overexertion during periods of reduced energy intake
Without clinical data, effectiveness remains largely unproven outside of anecdotal data