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Patients who are very overweight tend to lose more weight quicker than those of average weight initially after starting treatment

If transitioning from Tirzepatide, consult our Switching From Tirzepatide to Retatrutide Guide.

Retatrutide achieved greater weight loss in a shorter timeframe

The STEP 4 trial, which specifically examined continuation versus withdrawal of semaglutide, confirmed substantial weight regain in the discontinuation group

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If Foundayo's clinical outcomes hold up in real-world use (the Phase 3 ATTAIN-1 trial showed 11.2% mean weight loss at 72 weeks on the 36 mg dose, or 12.4% among participants who stayed on treatment), it could become the go-to affordable GLP-1 option and put downward pressure on Wegovy and Zepbound pricing