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Current mechanistic and pharmacodynamic understanding of melanocortin-4 receptor activation

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Beyond glucose control and weight reduction, GLP1RAs were shown to reduce cardiovascular morbidity and mortality and are therefore strongly recommended in early lines of diabetic therapy [3, 4]

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Elkins et al., 2006

1f, in agreement with the histopathological evaluation of the NAS score no evidences of fibrosis were found in mice fed a MCD diet for 3 weeks