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Call emergency services

Effects are typically mild and dose-related, with subcutaneous administration sometimes causing local responses

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In 1970, James Bartley and Roger Chalkley showed that histones of calf thymus nucleohistone are protease resistant when complexed with DNA, whereas when freed from DNA, they rapidly degraded, indicating the presence of DNA-binding-induced structure (Doolittle, 1973)

It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses