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4b), an ionizable LNP platform encapsulating a PROTAC targeting fragile X mental retardation protein (FMRP), enabling efficient tumor-targeted delivery and FMRP degradation, which synergized with immune checkpoint inhibitors to enhance anti-tumor immunity [187]

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Iacopetta B, Heyworth J, Girschik J, Grieu F, Clayforth C, Fritschi L