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For example, in the SURMOUNT-4 trial, tirzepatide discontinuers were randomized to a placebo, and they were unaware whether they were receiving tirzepatide or not. In real-world settings, the most common reasons for discontinuation are cost or insurance-related issues, and side effects, with the former predominating, he added

Unlike GLP-1 medications that target one or two pathways, surgery resets multiple signaling systems, creating a more comprehensive and permanent effect on weight regulation, says Dr

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Bottom line Managing digestive side effects from GLP-1 medications can feel frustrating, but support is available

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