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Semaglutide produced roughly 15% average body-weight loss in the STEP trials over 68 weeks (Wilding et al., N Engl J Med, 2021)

Drinking more than that can reduce the absorption of the medication

Instead, gradually increase fiber over the two weeks before you start

The PBAC will discuss this issue at its November 2025 meeting and provide advice to the Minister by end 2025. In a separate notification, the TGA also flagged it has issued 10 infringement notices to telehealth operator Midnight Health Pty Ltd for the alleged unlawful advertising of prescription-only weight-loss medicines

Remember that these medications are not a substitute for a balanced diet and regular exercise, but are used alongside these lifestyle modifications